ACUTE LEUKEMIAS

Massive practical value as clinicians are brought up to date on most recent advances in acute leukemia treatment
Authors delineate the development of new therapies
Lays out the current state of knowledge on the subject
Examines new classification systems that have been coming on stream

It is one of the most crucial areas of exploration in medicine today – and here is an important addition to the literature on the subject.
As research into cancers progresses, scientists are becoming ever more aware that better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells.
This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis.
Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia.
Their book also covers the management of acute leukemia in general as well as the development of new therapies.

Written for:

Hematologists, oncologists

Keywords:

• Classification
• Molecular Pathogenesis
• Prognoses
• Standard and New Therapies

Table of contents

Part I – Acute Myeloid Leukemia

1 Therapy of AML - E. H. Estey
2 Diagnosis and Classification of the Acute Myeloid Leukemias (with Discussion of the Role of the Myelodysplastic Syndromes
in AML Pathogenesis) - D. Head, M.A. Thompson
3 Acute Myeloid Leukemia: Epidemiology and Etiology - B. Deschler, M. Lübbert
4 Relapsed and Refractory Acute Myeloid Leukemia - S. Abutalib, M.S. Tallman

Part II – Acute Lymphoblastic Leukemia

5 Acute Lymphoblastic Leukemia: Epidemiology and Etiology - D. Wartenberg, F.D. Groves, A. S. Adelman
6 Molecular Biology and Genetics - M. Wetzler, M. Kryzstof
7 Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification - R. A. Larson, J. Anastasi
8 Diagnosis of Acute Lymphoblastic Leukemia - M. Albitar, F. J. Giles, H. Kantarjian
9 General Approach to the Therapy of Adult Acute Lymphoblastic Leukemia - S. H. Faderl, H.M. KantarjianÇ
10 Recent Clinical Trials in Acute Lymphoblastic Leukemia by the Cancer and Leukemia Group B - R. A. Larson, D. Yu, B.L. Sanford, W. Stock
11 Conventional Therapy in Adult Acute Lymphoblastic Leukemia: Review of the LALA Program - X. Thomas, D. Fiere
12 ALL Therapy: Review of the MD Anderson Program - S. H. Faderl, D. A. Thomas, H.M. Kantarjian
13 Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL) - N. Gökbuget, R. Arnold, A. Böhme, R. Fietkau, M. Freund, A. Ganser, M. Kneba, T. Lipp, W.-D. Ludwig, G. Maschmeyer, D. Messerer, H. Rieder, E. Thiel, D. Hoelzer for the German Multicenter Study Group for Adult ALL (GMALL)
14 Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia - O. Sala-Torra, J.P. Radich
15 Burkitt’s Acute Lymphoblastic Leukemia (L3ALL) in Adults - V. Ribrag, P. Casassus, P. Fenaux
16 Treatment of Lymphoblastic Lymphoma in Adults - N. Gökbuget, D. Hoelzer
17 The Role of Allogeneic Stem Cell Transplantation in the Therapy of Adult Acute Lymphoblastic Leukemia (ALL) - P. Kebriaei, R. Champlin
18 The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults - P. Kebriaei, S. Giralt
19 Novel Therapies in Acute Lymphoblastic Leukemia - S. H. Faderl, H.M. Kantarjian
20 Minimal Residual Disease Studies in Acute Lymphoblastic Leukemia - S. Abutalib, W. Stock
21 Central Nervous System Involvement in Adult Acute Lymphocytic Leukemia - R. H. Alvarez, J. E. Cortes
22 Relapsed Acute Lymphoblastic Leukemia - N. Lamanna, M. von Hassel, M. Weiss
23 Emergencies in Acute Lymphoblastic Leukemia - O. Frankfurt, M.S. Tallman
Subject Index