ANTITHROMBOTIC DRUG THERAPY IN CARDIOVASCULAR DISEASE

About this book

A thrombus, also called a blood clot, is an aggregation of platelets, fibrin, clotting factors, and the cellular elements of the blood attached to the interior wall of a vein or artery, sometimes occluding the lumen of the vessel. This book describes the mechanisms involved and how the various drugs work that have been developed to prevent and treat thrombi.

Written for: Cardiologists, interventional cardiologists and radiologists, vascular surgeons, and internists

Keywords:

• Antiplatelet therapies
• Antithrombotic therapies
• Atrial fibrillation
• Deep vein thrombosis
• Myocardial infarction
• Pulmonary embolism
• Thrombosis
• Unstable angina

Table of contents

Part I: Basic Principles

• The Link Between Inflammation and Thrombosis - James de Lemos
• The Platelet in Arterial and Venous Thrombosis - Edward F. Plow
• The Coagulation Cascade in Arterial and Venous Thrombosis - Kandice Marchant
• Genetics of Thrombosis - Marc S. Penn

Part II: Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease

• Aspirin for Primary and Secondary Prevention - Mike Lauer
• Clopidogrel and Thienopyridines in Stable CAD Patients - Marcus Flather

Part III: Antithrombotic Therapy for NSTE ACS

• Anti-platelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/IIIa Inhibitors - Deepak Bhatt
• Unfractionated Heparin and Enoxaparin:. - Elliott M. Antman
• The Direct Thrombin Inhibitors - A. Michael Lincoff
• Synthetic Factor Xa Inhibition, Fondaparinux - Shamir Mehta

Part IV: Antithrombotic Therapy for STEMI

• Antiplatelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/IIIa Inhibitors - Mark Sabatine
• Antithrombin Therapies: Unfractionated Heparin, Enoxaparin, Fondaparinux - Arman T. Askari
• Fibrinolysis and Facilitated PCI - Sorin J. Brener

Part V: Antithrombotic Therapy in Interventional Cardiology

• Antithrombotic Therapy in Percutaneous Coronary Intervention - Adrian W. Messerli
• Antithrombotic Therapy in Carotid and Peripheral Intervention - Samir Kapadia
• Monitoring of Antithrombotic Therapies - Steve Steinhubl

Part VI: Antithrombotic Therapy in Venous Thromboembolic Disease

• Antithrombotic Therapy for DVT/PE - John R. Bartholemew
• Fibrinolysis for PE - Heather Gornik
• Duration of Anticoagulation Following VTE - Samuel Goldhaber

Part VII: Clinical Considerations

Antithrombotic Therapy for Atrial Fibrillation - Allan Klein

Antithrombotic Therapy for Valvular Heart Disease- Brian Hoyt

Antithrombotic Therapy for Cardiomyopathy - Wilson Tang

Heparin-Induced Thrombocytopenia - Arman T. Askari

"Resistance" to Antiplatelet Therapies - Peter Berger