MOLECULAR PATHOLOGY. THE MOLECULAR BASIS OF HUMAN DISEASE

Description

Most "pathology" textbooks cover diseases and disease processes from the perspective of description (what does it look like and what are its characteristics), risk factors, disease-causing agents, and to some extent, cellular mechanisms. However, these books typically contain very sparse coverage (if any at all) of molecular mechanisms of disease. The reason for this is partially historical - most major forms of disease have been known for a long time, but the molecular basis of these diseases are not always known or have been elucidated only recently. Nevertheless, our overall understanding of the molecular and genetic mechanisms of the pathogenesis of most major human diseases has been advancing at a significant pace over the last two decades. As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, there is a need for a new textbook where molecular mechanisms represent the focus. Molecular Pathology focuses on the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.

Molecular Pathology is appropriate as a classroom teaching tool for medical students, biomedical graduate students, and some allied health students. In addition, it should be used as a reference book for practicing basic scientists and physician scientists that perform disease-related research. Further, this textbook will be valuable for pathology residents and other postdoctoral fellows who need to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Quotes

"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."
--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."
--Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore

Readership: Medical students, pathology graduate students, biomedical graduate students, and some allied health students.

Table of Contents

PART I: Essential Pathology - Mechanisms of Disease

Chapter 1: Molecular Mechanisms of Cell Death
John J. Lemasters, M.D., Ph.D., Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC

Chapter 2: Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D., Department of Pathology, University of Michigan, Ann Arbor, MI

Chapter 3: Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D., Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT

Chapter 4: Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC

PART II: Concepts in Molecular Biology and Genetics

Chapter 5: Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C., Molecular Genetics Laboratory, Mayo Clinic, Rochester, MN

Chapter 6: The Human Genome: Implications for the Understanding of Human Disease
Ashley Rivenbark, M.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC

Chapter 7: The Human Transcriptome: Implications for the Understanding of Human Disease
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D., Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charite-Universitatsmedizin Berlin, Berlin, Germany

Chapter 8: The Human Epigenome: Implications for the Understanding of Human Disease
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D., Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Madrid, Spain

Chapter 9: The Human Proteome: Implications for the Understanding of Human Disease
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin, The Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA

Chapter 10: Integrative Systems Biology: Implications for the Understanding of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA

PART III: Principles and Practice of Molecular Pathology

Chapter 11: Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC

Chapter 12: Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D., Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, and Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NH

Chapter 13: Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D., Computational Genetics Laboratory, Departments of Genetics and Pathology, Cotton Norris Cancer Center, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NH

PART IV: Molecular Pathology of Human Disease

Chapter 14: Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

Chapter 15: Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D., Departments of Medicine and Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC

Chapter 16: Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D., Department of Molecular and Experimental Medicine, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA

Chapter 17: Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D., Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Department of Medicine, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, California

Chapter 18: Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D., Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, and Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, OH

Chapter 19: Molecular Basis of Diseases of the Gastrointestinal Tract
Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia PA

Chapter 20: Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D., Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Chapter 21: Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D., Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt-University, Greifswald, Germany

Chapter 22: Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D., Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC

Chapter 23: Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D., Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Dana-Farber Harvard Cancer Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Chapter 24: Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D., Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

Chapter 25: Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard, Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium

Chapter 26: Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D., Genetic Skin Disease Group, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College and St. Thomas’ School of Medicine, London, UK

Chapter 27: Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D., Division of Neuropathology, Department of Pathology, University of Washington, Seattle, WA

PART V: Practice of Molecular Medicine

Chapter 28: Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D., Department of Pathology, University of Virginia Health System, Charlottesville, VA

Chapter 29: Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D., Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NH

Chapter 30: Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D., Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth University, Lebanon, NH

Author Information

Edited by William B. Coleman, Associate Professor and Director of Graduate Studies Department of Pathology and Laboratory Medicine Curriculum in Toxicology Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, USA; and Gregory J. Tsongalis, Associate Professor, Department of Pathology, Dartmouth Medical School and
Dartmouth Hitchcock Medical Center, Lebanon, NH, USA