AMYLOID AND RELATED DISORDERS, SURGICAL PATHOLOGY AND CLINICAL CORRELATIONS

ABOUT THIS BOOK

• Offers a rationale for various therapies.
• Provides a unifying concept of pathologic processes.
• Written by experts in the field.

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits.

Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Content Level » Professional/practitioner
Keywords » Abnormal protein deposition diseases - Amyloidoses - Cryoglobulinemia - Plasma cell dyscrasia - Renal pathology
Related subjects » Internal Medicine - Nephrology - Pathology

TABLE OF CONTENTS

Section 1 Introduction/General :

• 01.Aspects of the History and Nomenclature of Amyloid and Amyloidosis – Per Westermark
• 02.Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis – Mario Nuvolone, Giovanni Palladini, Giampaolo Merlini
• 03. AA Amyloidosis- Amanda K. Ombrello, Ivona Aksentijevich
• 04. The Hereditary Amyloidoses– Merrill D. Benson
• 05.Dialysis-Associated Amyloidosis- Paweena Susantitaphong, Laura M. Dember, Bertrand L. Jaber
• 06.Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System- Per Westermark
• 07.Cerebrovascular Amyloidoses- John M. Lee, Maria M. Picken

Section 2 Non-Amyloid Protein Deposits :

• 08. Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis- Guillermo A. Herrera, Elba A. Turbat-Herrera
• 09.Light / Heavy Chain Deposition Disease as a Systemic Disorder- Guillermo A. Herrera, Elba A. Turbat-Herrera
• 10. Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits- Pierre Ronco, Alexandre Karras, Emmanuelle Plaisier
• 11.Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond- Maria M. Picken

Section 3 Diagnosis :

• 12.Diagnosis of Amyloid Using Congo Red- Alexander J Howie
• 13.Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method - A Review- Reinhold P. Linke
• 14.Thioflavin T stain - An Easier and More Sensitive Method for Amyloid Detection- Maria M. Picken and Guillermo A. Herrera
• 15.Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis - Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg
• 16.Generic Diagnosis of Amyloid – a Summary of Current Recommendations and the Editorial Comments on Chapters 12 - 15.- Maria M. Picken
• 17.Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry- Reinhold P. Linke
• 18.Amyloid Typing – Experience from a Large Referral Centre - Janet A Gilbertson, Toby Hunt, Philip N. Hawkins
• 19.Options for Amyloid Typing in Renal Pathology – the Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chapters 17 – 19)- Maria M. Picken
• 20.Amyloid Typing: Immuno-Electron Microscopy - Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Vittorio Necchi, Marco Paulli, Giampaolo Merlini
• 21.Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Ahmet Dogan

Section 4 Ancillary Studies of Amyloidosis :

• 22.Laboratory Support for Diagnosis of Amyloidosis- David L Murray, Jerry A. Katzmann,
• 23.Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias- Sujata Ramamurthy, Lawreen H. Connors, Carl J. O’Hara
• 24.Laboratory Methods for the Diagnosis of Hereditary Amyloidoses- S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.

Section 5 Organ Involvement in Amyloidoses :

• 25.Amyloidoses of the Kidney and Genitourinary Tract- Maria M Picken
• 26.Cardiac Amyloidoses- Carmela D. Tan, E. Rene Rodriguez
• 27.Amyloidosis of the Gastrointestinal Tract and Liver- Oscar W. Cummings, Merrill D. Benson
• 28.Peripheral Nerve Amyloidosis- Adam J. Loavenbruck, Janean K. Engelstad, Christopher J. Klein

Section 6 Clinical Issues and Therapy :

• 29.Clinical and Pathologic Issues in Patients with Amyloidosis – Practical Comments Regarding Diagnosis, Therapy and Solid Organ Transplantation- Jay Dalal, Kevin Barton, Maria M. Picken
• 30.Emerging Therapies for Amyloidosis- Merrill D. Benson
• 31.Modern Therapies in AA Amyloidosis- Amanda K. Ombrello,
• 32.Medicolegal Issues of Amyloidosis- Timothy Craig Allen
• 33.Amyloidosis from the Patient’s Perspective- Muriel Finkel