CLINICAL DIAGNOSIS AND MANAGEMENT BY LABORATORY METHODS

Heres the revised, expanded, and updated New Edition of the gold standardin laboratory medicine. Readers will find comprehensive, integrated scientific guidance for diagnosis and clinical management as well as disease prevention and health promotion. The New Edition retains its focus on medical and laboratory problem-solvingenabling readers to develop a clear understanding of the order and sequence of lab tests, as well as the interpretation of resultsand incorporates the most current laboratory and diagnostic methods in use today.

Reviews

"There is no more venerable textbook in laboratory medicine and clinical pathology than this."Modern Pathology necessary text in every medical school and hospital library" Journal Of Occupational & Environmental Medicine

Features

• Delivers quick and easy access to information with a superb organisation that lends itself to continuous reading as well as specific, on-the-spot referencing of a particular problem or condition.
• Describes the fundamentals, basic science foundation, and clinical application of specific laboratory determinations.
• Enhances understanding with over 650 illustrations.
• Helps the clinician order tests in a cost-effective way.

What's New

• Incorporates the impact of molecular pathology throughout, including new advances in haematology, microbiology, parentage and identity testing, as well as genetic counselling.Explores hot topics such as new testing for the early detection of cancer
• assisted reproductive technology
• stem cell technology and tissue banking
• immunodeficiency disorders
• molecular pathology of infectious disease
• diagnostic array technology
• forensic DNA analysis
• and more.Includes expanded discussions of Polymerase Chain Reaction and other amplification methods
• diagnostic array technology
• the increased sensitivity and specificity that molecular pathology techniques have brought to cytogenetics
• and the incorporation of molecular techniques into the standard of practice in microbiology.Features current information on establishing and running a molecular diagnostics laboratorythoroughly updated to reflect the stringent new regulations in the U.S. and abroad.

Contents

PART I: The Clinical Laboratory
The Clinical Laboratory: Organization, Purpose and Practice
Physician Office Laboratories (POLS)
Principles of Instrumentation
Clinical Laboratory Automation
Interpreting Laboratory Results
Informatics, Imaging and Interoperability
Laboratory Statistics
Clinical Laboratory Quality Assurance

PART II: Clinical Chemistry
Evaluation of Renal Function, Wather, Electrolytes, Acid-Base Balance and Blood Gases
Metabolic Intermediates, Inorganic Ions and Biochemical Markers of Bone Metabolism
Carbohydrates
Lipids and Dyslipoproteinemia
Specific Proteins
Evaluation of Liver Function and Injury
Clinical Enzymology
Evaluation of Endocrine Function
Toxicology and Therapeutic Drug Monitoring

PART III: Urine and Other Body Fluids
Basic Examination of Urine
Cerebrospinal, Synovial, and Serious Body Fluids
Andrology Laboratory and Fertility Assessment
Laboratory Management of Assisted Reproductive Technology
Laboratory Aspects of Gestation Management
Laboratory Diagnosis of Gastrointestinal Tract and Pancreatic Disorders

PART IV: Hematology, Coagulation and Transfusion Medicine
Basic Examination of Blood
Hematopoiesis
Erythrocytic Disorders
Leukocytic Disorders
Blood Platelets
Coagulation, Fibrinolysis and Hypercoagulation
Immunohematology
Transfusion Medicine
Hemapheresis
Tissue Banking and Progenitor Cell

PART V: Immunology and Immunopathy
Overview of the Immune System and Immunologic Disorders
Immunoassays and Immunochemistry
Laboratory Evaluation of the Cellular Immune System
Laboratory Evaluation of Immunoglobin Function and Humoral Immunity
Complement and Kinins: Mediators of Inflamation
Cytokines and Adhesion Molecules
HLA: The Major Histocompatability Complex of Man
The Major Histocompatibility Complex and Disease
Immunodeficiency Disorders
Clinical and Laboratory Evaluation of Systemic Rheumatic Diseases
Vasculitis
Organ Specific Autoimmune Diseases
Allergic Diseases
Diagnosis and Management of Cancer Using Serologic Tumor Markers

PART VI: Medical Microbiology
Viral Infections
Chlamydial, Rickettsial, and Mycoplasmal Infections
Medical Microbiology
In Vitro Testing of Antimicrobial Agents
Spirochete Infections
Mycobacteria
Mycotic Diseases
Medical Parasitology
Molecular Pathology of Infectious Diseases
Specimen Collection and Handling for Diagnosis of Infectious Diseases

PART VII.: Molecular Pathology
An Introduction to Molecular Pathology
Molecular Diagnostics: Basic Principles and Techniques
Polymerase Chain Reaction (PCR) and Other Amplification Technology
Hybridization Array Technology
Applications for Cytogenetics in Modern Pathology
Establishing a Molecular Diagnostics Laboratory
Oncoproteins and Early Tumor Detection
Molecular Techniques in the Hematopoietic Neoplasms
Molecular Diagnosis of Genetic Diseases
Parentage Testing: Use of DNA Polymorphism and Other Genetic Markers
Forensic Identity Testing by DNA Analysis