WINTROBE'S CLINICAL HEMATOLOGY, 2 VOL.

Summary:

First published in 1942, Wintrobe’s Clinical Hematology continues its tradition of excellence in correlating basic science with the clinical practice of haematology. This is the most comprehensive haematology book on the market and is organised to help physicians find clinical answers quickly and easily. The Eleventh Edition places a greater emphasis on clinical haematology, especially molecular aspects and new therapies. Most chapters have been revised or reconfigured, and seven new chapters have been added: Gene Therapy, Congenital Immunodeficiency Syndromes, Acute Lymphocytic Leukemia in Adults, Acute Myelogenous Leukemia in Children, Acute Promyelocytic Leukemia, Systemic Mastocytosis, and Diagnosis and Classification of Lymphoproliferative Disorders.

Contents

Part 1. Laboratory Hematology

1. Examination of Blood and Bone Marrow
2. Clusters of Differentiation
3. Clinical Flow Cytometry
4. Cytogenetics
5. Molecular Genetics and Hematology

Part 2. The Normal Hematologic System

6. Origin and Development of Blood Cells
7. Erythropoiesis
8. The Mature Erythrocyte
9. Destruction of Erythrocytes
10. Neutrophilic Leukocytes
11. The Human Eosinophils
12. Basophilic Leukocytes: Mast Cells and Basophils
13. Mononuclear Phagocytes
14. Phagocytosis
15. The Lymphatic System
16. B Lymphocytes
17. T Lymphocytes and NK Cells
18. Cell Interactions in the Immune Response
19. Platelets and Megakaryocytes
20. Platelet Function in Hemostasis and Thrombosis
21. Blood Coagulation and Fibrinolysis
22. Endothelium and the Regulation of Hemostasis

Part 3. Therapeutic Modalities

23. Red Cell, Platelet, and White Cell Antigens
24. Transfusion Medicine
25. Hematopoietic Stem Cell Transplantation
26. Gene Therapy

Part 4. Disorders of Red Cells

27. Diagnostic Approach to Anemia
28. Iron Deficiency and Related Disorders
29. Sideroblastic Anemias
30. Hemochromatosis
31. Porphyria
32. Hemolytic Disorders: General Considerations
33. Hereditary Spherocytosis and Other Anemias Due to Abnormalities
34. Hereditary Hemolytic Anemias Due to Enzyme Abnormalities
35. Alloimmune Hemolytic Disease of the Fetus and Newborn
36. Autoimmune Hemolytic Anemias
37. Paroxysmal Nocturnal Hemoglobinuria
38. Acquired Non-Immune Hemolytic Disorders
39. The Abnormal Hemoglobins: General Principles
40. Sickle Cell Anemia and Other Sickling Syndromes
41. Unstable Hemoglobin Disease
42. The Thalassemias and Related Disorders: Quantitative Disorders
43. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
44. Acquired and Congenital Aplastic Anemia Syndromes
45. Pure Red Cell Aplasia in Children and Adults
46. Congenital Dyserythropoietic Anemias
47. Anemias Secondary to Chronic Disease and Systemic Disorders
48. Anemias Unique to Pregnancy and the Perinatal Period
49. Methemoglobinemia
50. Erythrocytosis

Part 5. Disorders of Hemostasis and Coagulation

51. The Diagnostic Approach to the Bleeding Disorders
52. Thrombocytopenia: Pathophysiology/Classification
53. Thrombocytopenia Caused by Immunolgic Platelet Destruction
54. Thrombotic Thrombocytopenic Purpura and Other Forms…
55. Miscellaneous Causes of Thrombocytopenia
56. Bleeding Disorders Caused by Vascular Abnormalities
57. Thrombocytosis
58. Qualitative Disorders of Platelet Function
59. Inherited Coagulation Disorders
60. Acquired Coagulation Disorders
61. Thrombosis and Antithrombotic Therapy

Part 6. Nonmalignant Disorders of Leukocytes, the Spleen, and/or Immunoglobins

62. Diagnostic Approach to Disorders…
63. Neutropenia
64. Qualitative Disorders of Leukocytes
65. Abnormalities of the Monocyte-Macrophage System--The Lysosomal…
66. Langerhans Cell Histiocytosis
67. Infectious Mononucleosis and Other EBV-Related Disorders
68. Congenital Immune Deficiencies
69. Acquired Immunodeficiency Disease
70. Disorders of the Spleen

Part 7. Hematologic Malignancies

71. The Hematopoietic and Lymphoid Neoplasms: Principles of Diagnosis
72. Complications of Hematopoietic Neoplasms
73. Principles and Pharmacology of Chemotherapy
74. Immunotherapy
75. Supportive Care in Hematologic Malignancies
76. Classification and Differentiation of the Acute Leukemias
77. Molecular Genetics of Acute Leukemia
78. Acute Lymphocytic Leukemia in Children
79. Acute Lymphocytic Leukemia in Adults
80. Acute Myelogenous Leukemia in Adults
81. Acute Myelogenous Leukemia in Children
82. Acute Promyelocytic Leukemia
83. The Myelodysplastic Syndromes
84. Chronic Myeloid Leukemia
85. Polycythemia Vera
86. Myelofibrosis
87. Systemic Mastocytosis
88. Diagnosis and Classification of Lymphoproliferative Disorders
89. Molecular Aspects of Non-Hodgkin Lymphomagenesis
90. Non-Hodgkin Lymphomas in Adults
91. Non-Hodgkin Lymphomas in Children
92. Chronic Lymphocytic Leukemia
93. Hairy Cell Leukemia
94. Cutaneous T-Cell Lymphomas: Mycosis Fungiodes and Sezary Syndrome
95. Hodgkin Disease
96. Plasma Cell Disorders: General Considerations
97. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
98. Multiple Myeloma
99. Amyloidosis
100. Waldenstrom's Macroglobulinemia 101. Cryoglobulinemia, Heavy Chain Diseases and Monoclonal Gammopathy Associated Disorders

Appendix A.

Normal Blood and Bone Marrow Values in Humans

Appendix B.

Comparative Hematology