CLINICAL AND BIOCHEMICAL DISORDERS OF THE SKELETON

Description
A clear and definitive reference for clinical management of disorders of the skeleton
Covers common, as well as rare disorders that even the most experienced clinicians may be unfamiliar with
Emphasises new advances made in bone cell biology and human skeletal disease as a result of molecular medicine
Highly illustrated with numerous half tones and line drawings
Essential reading for general physicians, rheumatologists and orthopaedic surgeons in training

This book is the definitive guide on the subject. It comprehensively covers common polygenic and rare monogenic disorders and emphasizes the new advances which have been made in bone cell biology and in human skeletal disease, particularly as a result of molecular medicine. This accessible and well-illustrated book is written for postgraduates and clinicians who find disorders of the skeleton mysterious, and for whom an understandable explanation has been hard to find. It will be of particular interest to those who look after patients with a wide variety of metabolic bone diseases, including general physicians, rheumatologists, endocrinologists and orthopaedic surgeons, and contains new information of interest to paediatricians and geneticists.

Readership: Rheumatologists, orthopaedic surgeons in training, endocrinologists, paediatricians and radiologists.

Contents
Introduction
The physiology and pathology of bone
Diagnosis and investigation
Osteoporosis
Osteomalacia and rickets
Parathyroids and skeleton
Paget's disease
Neoplastic disease and other non-parathyroid causes of hypercalcaemia
Osteogenesis imperfecta
Chondrodysplasias
Osteopetrosis and osteosclerosis
The Marfan syndrome and related disorders
Ehlers Danlos syndrome and related disorders
Enzyme defects and the skeleton
Fibrous dysplasia
Fibrogenesis imperfecta ossium (FIO) and other disorders of mineralization
Ectopic mineralization
Recent advances
Appendix

Authors, editors, and contributors
Roger Smith, Honorary Consultant Physician, Nuffield Orthopaedic Centre, Oxford, UK and Paul Wordsworth, Professor of Clinical Rheumatology, Nuffield Orthopaedic Centre, Oxford, UK