Extensively reorganized and revised with the latest data from this rapidly changing field, Lewin's Essential GENES, Third Edition, provides students with a comprehensive overview of molecular biology and molecular genetics. The authors took care to carefully modify the chapter order in an effort to provide a more clear and student-friendly presentation of course material. Chapter material has been updated throughout, including a completely revised chapter on regulatory RNA, to keep pace with this advancing field. The Third Edition's exceptional pedagogy enhances student learning and helps readers understand and retain key material like never before. Concept and Reasoning Checks at the end of each chapter section, End-of-Chapter Questions and Further Readings sections, as well as several categories of special topics boxes, expand and reinforce important concepts.
- Reorganized chapter presentation provides a clear, student-friendly introduction to course material.
- Completely revised chapter on Regulatory RNA provides new information in this rapidly advancing field.
- The four replication chapters have been completely reorganized and include new sections describing eukaryote cell cycle control of replication.
- Special Topics Boxes provide a balanced approach and serve to promote greater understanding of key material. These boxes fall into four-categories:
- Essential Ideas boxes reinforce and clearly explain concepts critical to the chapter topics.
- Medical Applications boxes provide clear links between basic molecular principles and human health
- Historical Perspectives boxes supply the background information or experimental paths that led to our current knowledge
- Methods and Techniques boxes describe how powerful methods in molecular biology are performed
- Concept and Reasoning Checks consist of one or two questions at the end of each chapter section that ask students to pause and assess their understanding of the material they have just read. These questions require critical thinking or integration of section topics.
- Key Concepts comprise bulleted lists of important points that follow each chapter section.
- Further Readings at the end of every chapter direct students to current review articles and seminal research papers, providing further sources of information to reinforce and elaborate on chapter material.
Table of Contents
- Part I Genes and Chromosomes
- Chapter 1 Genes Are DNA
- Chapter 2 Genes Code for Proteins
- Chapter 3 Methods in Molecular Biology and Genetic Engineering
- Chapter 4 The Interrupted Gene
- Chapter 5 The Content of the Genome
- Chapter 6 Genome Sequences and Gene Number
- Chapter 7 Clusters and Repeats
- Chapter 8 Genome Evolution
- Chapter 9 Chromosomes
- Chapter 10 Chromatin
- Part II DNA Replication and Recombination
- Chapter 11 Replication is Connected to the Cell Cycle
- Chapter 12 The Replicon: Initiation of Replication
- Chapter 13 DNA Replication
- Chapter 14 Extrachromosomal Replication
- Chapter 15 Homologous and Site-Specific Recombination
- Chapter 16 Repair Systems
- Chapter 17 Transposons, Retroviruses and Retrotransposons
- Chapter 18 Immune Diversity
- Part III Gene Expression
- Chapter 19 Prokaryotic Transcription
- Chapter 20 Eukaryotic Transcription
- Chapter 21 RNA Splicing and Processing
- Chapter 22 mRNA Stability and Localization
- Chapter 23 Catalytic RNA
- Chapter 24 Translation
- Chapter 25 Using the Genetic Code
- Part IV Gene Regulation
- Chapter 26 The Operon
- Chapter 27 Phage Strategies
- Chapter 28 Eukaryotic Transcription Regulation
- Chapter 29 Epigenetic Effects are Inherited
- Chapter 30 Regulatory RNA
About the Author
Jocelyn E. Krebs, PhD-Associate Professor, University of Alaska, Anchorage has been a member of the Department of Biological Sciences at the University of Alaska Anchorage since 2000. She received her B.A. in Biological Sciences from Bard College in 1991 and her PhD in Molecular and Cell Biology from the University of California Berkeley in 1997. Her research focuses on the mechanisms by which DNA transactions such as transcription and repair are accomplished in the context of chromatin. Her teaching interests are in Molecular Biology (taught at the undergraduate, graduate, and first-year medical school levels), as well as the Molecular Biology of Cancer.